“Millions of people are undergoing treatments for cardiovascular diseases. It also predicts how the cells communicate to keep the heart working. Part of the Human Cell Atlas initiative, the research shows the huge diversity of cells and reveals heart muscle cell types, cardiac protective immune cells, and an intricate network of blood vessels. The team analyzed almost a half million individual cells to build the most extensive cell atlas of the human heart to date. The study, published in the journal Nature, was led by investigators at Harvard Medical School, Harvard-affiliated Brigham and Women’s Hospital, the Wellcome Sanger Institute, Max Delbrück Center for Molecular Medicine (MDC) in Germany, Imperial College London, and their global collaborators. Their work gives a better understanding of how this vital organ functions, and could shed light on what goes awry in cardiovascular disease. HSCI researchers are part of a cross-institutional team of scientists that has created a detailed cellular and molecular map of the healthy human heart. ACE2 (red dots), a receptor targeted by SARS-CoV-2, was enriched in these cell types.
Tissue from the right ventricle of a heart shows fibroblasts and pericytes, with cell nuclei in blue.
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